Synaptic Plasticity
The ability of synapses to strengthen or weaken over time in response to changes in activity. The cellular basis of learning and memory.
In Depth
The endocannabinoid system is a master regulator of synaptic plasticity. Endocannabinoids mediate multiple forms of short-term (DSI, DSE) and long-term (LTD, LTP) plasticity. THC disrupts hippocampal LTP — the synaptic mechanism underlying memory formation — explaining its acute amnestic effects. Conversely, ECS-mediated plasticity is essential for normal learning, and FAAH inhibitors that enhance endocannabinoid tone may improve certain forms of learning in animal models.
Related Terms
More in Neuroscience
Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
Neurogenesis
The process by which new neurons are formed in the brain. In adults, primarily occurs in the hippocampus (dentate gyrus) and olfactory bulb.
Neuroprotection
The preservation of neuronal structure and function against injury, degeneration, or disease.
Neuroinflammation
Inflammation of nervous tissue, involving activation of microglia and astrocytes and release of pro-inflammatory cytokines within the CNS.
Hippocampus
A brain region critical for memory formation, spatial navigation, and stress regulation. Highly enriched in CB1 receptors and particularly sensitive to cannabinoid effects.