Neurogenesis
The process by which new neurons are formed in the brain. In adults, primarily occurs in the hippocampus (dentate gyrus) and olfactory bulb.
In Depth
Cannabinoids, particularly CBD and THC, have been shown to promote hippocampal neurogenesis in animal models. This effect may contribute to the antidepressant and anxiolytic properties of cannabinoids, as reduced hippocampal neurogenesis is associated with depression and stress. Chronic THC use, conversely, may impair neurogenesis in some models. The clinical relevance of cannabinoid-induced neurogenesis in humans remains under investigation.
Related Terms
Further Reading
More in Neuroscience
Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
Neuroprotection
The preservation of neuronal structure and function against injury, degeneration, or disease.
Neuroinflammation
Inflammation of nervous tissue, involving activation of microglia and astrocytes and release of pro-inflammatory cytokines within the CNS.
Hippocampus
A brain region critical for memory formation, spatial navigation, and stress regulation. Highly enriched in CB1 receptors and particularly sensitive to cannabinoid effects.
Amygdala
A brain region central to fear processing, emotional memory, and the stress response. CB1 receptors in the amygdala mediate cannabinoids' effects on anxiety and fear extinction.