Prefrontal Cortex (PFC)
The anterior region of the frontal lobe responsible for executive function, decision-making, working memory, and impulse control. A key site of THC's cognitive effects.
In Depth
The PFC undergoes prolonged development into the mid-20s, making it particularly vulnerable to cannabinoid disruption during adolescence. THC impairs PFC-dependent functions including working memory, attention, and cognitive flexibility via CB1 receptor activation. Neuroimaging studies show altered PFC activation patterns in chronic cannabis users. The PFC also regulates the amygdala's fear response — PFC-amygdala connectivity is modulated by the endocannabinoid system and is relevant to anxiety and PTSD.
Related Terms
Further Reading
More in Neuroscience
Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
Neurogenesis
The process by which new neurons are formed in the brain. In adults, primarily occurs in the hippocampus (dentate gyrus) and olfactory bulb.
Neuroprotection
The preservation of neuronal structure and function against injury, degeneration, or disease.
Neuroinflammation
Inflammation of nervous tissue, involving activation of microglia and astrocytes and release of pro-inflammatory cytokines within the CNS.
Hippocampus
A brain region critical for memory formation, spatial navigation, and stress regulation. Highly enriched in CB1 receptors and particularly sensitive to cannabinoid effects.