Hippocampus
/hip-oh-KAM-pus/
A brain region critical for memory formation, spatial navigation, and stress regulation. Highly enriched in CB1 receptors and particularly sensitive to cannabinoid effects.
In Depth
The hippocampus has the highest density of CB1 receptors in the brain. THC's acute impairment of short-term memory is mediated primarily through CB1 receptor activation in the hippocampus, disrupting long-term potentiation (LTP). Chronic heavy cannabis use is associated with reduced hippocampal volume and altered hippocampal function in neuroimaging studies. Conversely, CBD and low-dose THC promote hippocampal neurogenesis in animal models, which may contribute to antidepressant effects.
Related Terms
Further Reading
More in Neuroscience
Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
Neurogenesis
The process by which new neurons are formed in the brain. In adults, primarily occurs in the hippocampus (dentate gyrus) and olfactory bulb.
Neuroprotection
The preservation of neuronal structure and function against injury, degeneration, or disease.
Neuroinflammation
Inflammation of nervous tissue, involving activation of microglia and astrocytes and release of pro-inflammatory cytokines within the CNS.
Amygdala
A brain region central to fear processing, emotional memory, and the stress response. CB1 receptors in the amygdala mediate cannabinoids' effects on anxiety and fear extinction.