Neuroinflammation
Inflammation of nervous tissue, involving activation of microglia and astrocytes and release of pro-inflammatory cytokines within the CNS.
In Depth
Neuroinflammation is implicated in virtually all neurodegenerative diseases including Alzheimer's, Parkinson's, ALS, and multiple sclerosis. CB2 receptors are upregulated on activated microglia during neuroinflammation, making them attractive therapeutic targets. CBD and selective CB2 agonists have shown anti-neuroinflammatory effects in preclinical models. The relationship between cannabis use and neuroinflammation in humans is complex and bidirectional.
Related Terms
Further Reading
More in Neuroscience
Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
Neurogenesis
The process by which new neurons are formed in the brain. In adults, primarily occurs in the hippocampus (dentate gyrus) and olfactory bulb.
Neuroprotection
The preservation of neuronal structure and function against injury, degeneration, or disease.
Hippocampus
A brain region critical for memory formation, spatial navigation, and stress regulation. Highly enriched in CB1 receptors and particularly sensitive to cannabinoid effects.
Amygdala
A brain region central to fear processing, emotional memory, and the stress response. CB1 receptors in the amygdala mediate cannabinoids' effects on anxiety and fear extinction.