Topical Cannabis
Cannabis preparations applied directly to the skin for local effects. Topical cannabinoids act on peripheral CB1 and CB2 receptors without significant systemic absorption.
In Depth
Topical cannabis products (creams, balms, patches) deliver cannabinoids to peripheral tissues including skin, muscle, and joints. CB1 and CB2 receptors in the skin mediate local anti-inflammatory and analgesic effects. Topical cannabinoids do not produce psychoactive effects because systemic absorption is minimal (<1% without permeation enhancers). Transdermal patches with permeation enhancers can achieve systemic delivery. Clinical evidence for topical cannabinoids is limited but promising for conditions like arthritis and dermatitis.
More in Chemistry
Decarboxylation
The chemical process by which a carboxyl group (COOH) is removed from a molecule, releasing CO₂. Converts inactive cannabinoid acids (THCA, CBDA) into their active forms (THC, CBD).
THCA (Tetrahydrocannabinolic Acid)
The acidic, non-psychoactive precursor to THC found in raw, unheated cannabis. Converted to THC through decarboxylation.
CBDA (Cannabidiolic Acid)
The acidic precursor to CBD found in raw cannabis. Converted to CBD through decarboxylation.
Lipophilicity
The tendency of a molecule to dissolve in fats, oils, and non-polar solvents rather than water. Cannabinoids are highly lipophilic.
Myrcene
The most abundant terpene in most cannabis strains. Produces an earthy, musky aroma. Proposed to enhance cannabinoid absorption and contribute to sedating effects.