CBDA (Cannabidiolic Acid)
The acidic precursor to CBD found in raw cannabis. Converted to CBD through decarboxylation.
In Depth
CBDA is a selective COX-2 inhibitor with anti-inflammatory properties. It is also a potent 5-HT1A receptor agonist — more potent than CBD itself — suggesting potential anxiolytic and antiemetic activity. GW Pharmaceuticals has investigated CBDA methyl ester (HU-580) as a more stable CBDA derivative for nausea and anxiety. CBDA's instability (rapid conversion to CBD) has historically limited research, but interest is growing.
Related Terms
Further Reading
More in Chemistry
Decarboxylation
The chemical process by which a carboxyl group (COOH) is removed from a molecule, releasing CO₂. Converts inactive cannabinoid acids (THCA, CBDA) into their active forms (THC, CBD).
THCA (Tetrahydrocannabinolic Acid)
The acidic, non-psychoactive precursor to THC found in raw, unheated cannabis. Converted to THC through decarboxylation.
Lipophilicity
The tendency of a molecule to dissolve in fats, oils, and non-polar solvents rather than water. Cannabinoids are highly lipophilic.
Myrcene
The most abundant terpene in most cannabis strains. Produces an earthy, musky aroma. Proposed to enhance cannabinoid absorption and contribute to sedating effects.
Limonene
A citrus-scented terpene found in cannabis and citrus fruits. Associated with anxiolytic and antidepressant effects in preclinical studies.