Oxidative Stress
An imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to cellular damage. CBD is a potent antioxidant that reduces oxidative stress.
In Depth
Oxidative stress contributes to neurodegeneration, cardiovascular disease, cancer, and aging. CBD has demonstrated antioxidant activity comparable to vitamins C and E in some assays, scavenging free radicals and reducing ROS production. The US government holds a patent (US6630507) on cannabinoids as antioxidants and neuroprotectants. THC also has antioxidant properties but its psychoactivity limits therapeutic application at doses needed for antioxidant effects.
Related Terms
More in Pharmacology
Endocannabinoid System (ECS)
A lipid-based retrograde neurotransmitter system comprising endogenous cannabinoids (endocannabinoids), their receptors (CB1, CB2), and metabolic enzymes.
CB1 Receptor
Cannabinoid receptor type 1. A G protein-coupled receptor (GPCR) primarily expressed in the central nervous system. The primary target of THC's psychoactive effects.
CB2 Receptor
Cannabinoid receptor type 2. A GPCR primarily expressed in immune tissues and peripheral organs. Less abundant in the CNS than CB1.
Anandamide (AEA)
N-arachidonoylethanolamine. The first endocannabinoid identified. A partial agonist at CB1 and CB2 receptors, named from the Sanskrit word "ananda" meaning bliss.
2-Arachidonoylglycerol (2-AG)
The most abundant endocannabinoid in the brain. A full agonist at both CB1 and CB2 receptors.