Metabolite
A product of drug metabolism. THC's primary metabolites are 11-OH-THC (active) and 11-COOH-THC (inactive, used in drug testing).
In Depth
THC undergoes extensive hepatic metabolism. The primary metabolite, 11-OH-THC, is pharmacologically active and more potent than THC at CB1 receptors — contributing to the intense effects of oral cannabis. 11-OH-THC is further metabolized to 11-COOH-THC (THC-COOH), which is inactive but highly lipophilic and accumulates in fat tissue, explaining the prolonged detection window in drug tests. CBD is metabolized to 7-OH-CBD and CBD-7-oic acid, which are largely inactive.
Related Terms
More in Chemistry
Decarboxylation
The chemical process by which a carboxyl group (COOH) is removed from a molecule, releasing CO₂. Converts inactive cannabinoid acids (THCA, CBDA) into their active forms (THC, CBD).
THCA (Tetrahydrocannabinolic Acid)
The acidic, non-psychoactive precursor to THC found in raw, unheated cannabis. Converted to THC through decarboxylation.
CBDA (Cannabidiolic Acid)
The acidic precursor to CBD found in raw cannabis. Converted to CBD through decarboxylation.
Lipophilicity
The tendency of a molecule to dissolve in fats, oils, and non-polar solvents rather than water. Cannabinoids are highly lipophilic.
Myrcene
The most abundant terpene in most cannabis strains. Produces an earthy, musky aroma. Proposed to enhance cannabinoid absorption and contribute to sedating effects.