Flavonoids
A class of polyphenolic plant compounds found in cannabis alongside cannabinoids and terpenes. Some cannabis-specific flavonoids (cannflavins) have potent anti-inflammatory properties.
In Depth
Cannabis contains approximately 20 flavonoids, including quercetin, kaempferol, apigenin, and the cannabis-specific cannflavins A and B. Cannflavin A inhibits prostaglandin E2 production 30 times more potently than aspirin in vitro. Flavonoids contribute to the color of cannabis flowers and may contribute to the entourage effect. They are largely destroyed by combustion, making vaporization or oral consumption preferable for preserving flavonoid content.
More in Chemistry
Decarboxylation
The chemical process by which a carboxyl group (COOH) is removed from a molecule, releasing CO₂. Converts inactive cannabinoid acids (THCA, CBDA) into their active forms (THC, CBD).
THCA (Tetrahydrocannabinolic Acid)
The acidic, non-psychoactive precursor to THC found in raw, unheated cannabis. Converted to THC through decarboxylation.
CBDA (Cannabidiolic Acid)
The acidic precursor to CBD found in raw cannabis. Converted to CBD through decarboxylation.
Lipophilicity
The tendency of a molecule to dissolve in fats, oils, and non-polar solvents rather than water. Cannabinoids are highly lipophilic.
Myrcene
The most abundant terpene in most cannabis strains. Produces an earthy, musky aroma. Proposed to enhance cannabinoid absorption and contribute to sedating effects.