Cannabigerolic Acid (CBGA)
/kan-uh-bih-JER-oh-lik/
The biosynthetic precursor to all major cannabinoids. Often called the "stem cell" of cannabinoids. Converted to THCA, CBDA, and CBCA by specific synthase enzymes.
In Depth
CBGA is synthesized in cannabis trichomes from olivetolic acid and geranyl pyrophosphate by the enzyme CBGA synthase. Three branch-point enzymes then convert CBGA into the major cannabinoid acids: THCA synthase (→ THCA), CBDA synthase (→ CBDA), and CBCA synthase (→ CBCA). Any remaining CBGA is decarboxylated to CBG. The ratio of these enzymes determines the cannabinoid profile of a given cannabis strain. CBGA itself has demonstrated anti-inflammatory and antibacterial properties in preclinical studies.
Related Terms
Further Reading
More in Cannabinoids
Cannabidiol (CBD)
A non-intoxicating phytocannabinoid found in Cannabis sativa. The second most abundant cannabinoid in most cannabis strains.
Tetrahydrocannabinol (THC)
The primary psychoactive cannabinoid in cannabis. A partial agonist at CB1 and CB2 receptors.
Cannabigerol (CBG)
A non-intoxicating cannabinoid often called the "mother cannabinoid" — the biosynthetic precursor from which THC, CBD, and CBC are synthesized.
Cannabinol (CBN)
A mildly psychoactive cannabinoid formed by the oxidative degradation of THC. Accumulates as cannabis ages or is exposed to heat and light.
Cannabichromene (CBC)
A non-intoxicating phytocannabinoid that does not bind significantly to CB1 or CB2 receptors but interacts with TRP channels.