Anti-Inflammatory
A property of substances that reduce inflammation. Both CBD and THC have anti-inflammatory effects, primarily through CB2 receptor activation and cytokine modulation.
In Depth
Cannabinoid anti-inflammatory mechanisms include: CB2 receptor-mediated reduction of pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6), inhibition of NF-κB signaling, activation of PPAR-γ (CBD), and reduction of arachidonic acid metabolism. CBD's anti-inflammatory effects are particularly well-documented in preclinical models of neuroinflammation, arthritis, and IBD. Clinical evidence for anti-inflammatory effects in humans is emerging but requires larger trials.
Related Terms
Further Reading
More in Clinical
Dravet Syndrome
A severe, treatment-resistant form of childhood epilepsy characterized by prolonged seizures, often triggered by fever, beginning in the first year of life.
Lennox-Gastaut Syndrome (LGS)
A severe form of childhood-onset epilepsy characterized by multiple seizure types, slow spike-wave EEG pattern, and cognitive impairment.
Epidiolex
The FDA-approved pharmaceutical formulation of purified cannabidiol (CBD), manufactured by GW Pharmaceuticals (now Jazz Pharmaceuticals). Approved in 2018 for Dravet syndrome and Lennox-Gastaut syndrome.
Dronabinol (Marinol)
A synthetic form of THC (Δ9-tetrahydrocannabinol) approved by the FDA for chemotherapy-induced nausea/vomiting and AIDS-related anorexia.
Nabilone (Cesamet)
A synthetic cannabinoid analogue of THC approved for chemotherapy-induced nausea and vomiting. More potent than dronabinol.