Analgesic
/an-ul-JEE-zik/
A pain-relieving drug. Cannabinoids act as analgesics through multiple mechanisms including CB1/CB2 receptor activation, TRPV1 modulation, and anti-inflammatory effects.
In Depth
Cannabinoid analgesia involves both central and peripheral mechanisms. Centrally, CB1 receptor activation in the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) activates descending pain inhibition pathways. Peripherally, CB1 and CB2 receptors on nociceptors reduce pain signal transmission. Cannabinoids are particularly effective for neuropathic pain, where conventional analgesics often fail. The combination of THC and CBD may produce synergistic analgesia.
Related Terms
Further Reading
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