PPAR-γ (Peroxisome Proliferator-Activated Receptor Gamma)
A nuclear receptor that regulates gene expression related to metabolism, inflammation, and cell differentiation. CBD and some endocannabinoids are PPAR-γ agonists.
In Depth
PPAR-γ is a transcription factor that, when activated, reduces inflammation, improves insulin sensitivity, and promotes adipogenesis. CBD's PPAR-γ agonism may contribute to its anti-inflammatory, neuroprotective, and metabolic effects. PPAR-γ activation also promotes cancer cell apoptosis in some tumor types. Thiazolidinediones (diabetes drugs like pioglitazone) work through PPAR-γ — CBD's similar mechanism may explain its metabolic effects. PPAR-γ is an important non-cannabinoid receptor target for CBD.
Related Terms
More in Pharmacology
Endocannabinoid System (ECS)
A lipid-based retrograde neurotransmitter system comprising endogenous cannabinoids (endocannabinoids), their receptors (CB1, CB2), and metabolic enzymes.
CB1 Receptor
Cannabinoid receptor type 1. A G protein-coupled receptor (GPCR) primarily expressed in the central nervous system. The primary target of THC's psychoactive effects.
CB2 Receptor
Cannabinoid receptor type 2. A GPCR primarily expressed in immune tissues and peripheral organs. Less abundant in the CNS than CB1.
Anandamide (AEA)
N-arachidonoylethanolamine. The first endocannabinoid identified. A partial agonist at CB1 and CB2 receptors, named from the Sanskrit word "ananda" meaning bliss.
2-Arachidonoylglycerol (2-AG)
The most abundant endocannabinoid in the brain. A full agonist at both CB1 and CB2 receptors.