Pharmacogenomics
The study of how genetic variation affects drug response. Genetic differences in CYP450 enzymes and cannabinoid receptors contribute to the wide variability in cannabis response.
In Depth
Individual variation in cannabis response is substantial and partly genetically determined. CYP2C9 polymorphisms affect THC and CBD metabolism — poor metabolizers have higher plasma levels and more pronounced effects. CNR1 gene variants (encoding CB1 receptors) are associated with differences in cannabis dependence risk and therapeutic response. FAAH gene variants affect anandamide levels and anxiety. Pharmacogenomic testing may eventually guide personalized cannabinoid therapy, though clinical implementation is not yet standard.
Related Terms
More in Research Methods
Randomized Controlled Trial (RCT)
The gold standard study design in clinical research. Participants are randomly assigned to treatment or control groups to minimize bias and establish causation.
Systematic Review
A structured synthesis of all available evidence on a specific research question, using predefined criteria to identify, evaluate, and summarize studies.
Meta-Analysis
A statistical technique that combines quantitative data from multiple studies to produce a pooled estimate of effect size with greater statistical power than any individual study.
Placebo-Controlled
A study design in which the control group receives an inert substance (placebo) identical in appearance to the active treatment, to account for the placebo effect.
Observational Study
A study in which researchers observe participants without intervening. Includes cohort studies, case-control studies, and cross-sectional surveys.