Real-World Evidence (RWE)
Clinical evidence derived from analysis of real-world data (electronic health records, registries, claims data) outside of controlled clinical trials.
In Depth
RWE is increasingly important in cannabis research because the regulatory barriers to RCTs have limited the evidence base. Patient registries (e.g., UK Medical Cannabis Registry, Australian TGA registry) collect systematic data on medical cannabis use and outcomes in real-world populations. RWE can identify patient subgroups most likely to benefit, long-term safety signals, and real-world dosing patterns. While RWE cannot establish causation, it complements RCT evidence and is increasingly accepted by regulators.
Related Terms
More in Research Methods
Randomized Controlled Trial (RCT)
The gold standard study design in clinical research. Participants are randomly assigned to treatment or control groups to minimize bias and establish causation.
Systematic Review
A structured synthesis of all available evidence on a specific research question, using predefined criteria to identify, evaluate, and summarize studies.
Meta-Analysis
A statistical technique that combines quantitative data from multiple studies to produce a pooled estimate of effect size with greater statistical power than any individual study.
Placebo-Controlled
A study design in which the control group receives an inert substance (placebo) identical in appearance to the active treatment, to account for the placebo effect.
Observational Study
A study in which researchers observe participants without intervening. Includes cohort studies, case-control studies, and cross-sectional surveys.