Synthetic Cannabinoid
A laboratory-synthesized compound designed to interact with cannabinoid receptors. Includes pharmaceutical cannabinoids (dronabinol, nabilone) and illicit "designer" cannabinoids (Spice, K2).
In Depth
Synthetic cannabinoids span a wide spectrum. Pharmaceutical synthetics (dronabinol, nabilone) are FDA-approved and well-characterized. Research synthetics (WIN 55,212-2, JWH-018) are used in preclinical studies. Illicit synthetic cannabinoids (marketed as "Spice," "K2," or "synthetic marijuana") are full CB1 agonists — unlike THC which is a partial agonist — producing far more intense and unpredictable effects. Illicit synthetics have caused numerous deaths and are associated with seizures, psychosis, and cardiovascular events.
Related Terms
More in Cannabinoids
Cannabidiol (CBD)
A non-intoxicating phytocannabinoid found in Cannabis sativa. The second most abundant cannabinoid in most cannabis strains.
Tetrahydrocannabinol (THC)
The primary psychoactive cannabinoid in cannabis. A partial agonist at CB1 and CB2 receptors.
Cannabigerol (CBG)
A non-intoxicating cannabinoid often called the "mother cannabinoid" — the biosynthetic precursor from which THC, CBD, and CBC are synthesized.
Cannabinol (CBN)
A mildly psychoactive cannabinoid formed by the oxidative degradation of THC. Accumulates as cannabis ages or is exposed to heat and light.
Cannabichromene (CBC)
A non-intoxicating phytocannabinoid that does not bind significantly to CB1 or CB2 receptors but interacts with TRP channels.