Endocannabinoid
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A cannabinoid produced naturally within the body that activates cannabinoid receptors. The two primary endocannabinoids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG).
In Depth
Endocannabinoids are lipid-based neurotransmitters synthesized on demand from membrane phospholipids, unlike classical neurotransmitters which are stored in vesicles. They are released from postsynaptic neurons and act retrogradely on presynaptic CB1 receptors to modulate neurotransmitter release. Beyond AEA and 2-AG, other endocannabinoid-like molecules include noladin ether, virodhamine, and N-arachidonoyl-dopamine (NADA), though their physiological roles are less established.
Further Reading
More in Cannabinoids
Cannabidiol (CBD)
A non-intoxicating phytocannabinoid found in Cannabis sativa. The second most abundant cannabinoid in most cannabis strains.
Tetrahydrocannabinol (THC)
The primary psychoactive cannabinoid in cannabis. A partial agonist at CB1 and CB2 receptors.
Cannabigerol (CBG)
A non-intoxicating cannabinoid often called the "mother cannabinoid" — the biosynthetic precursor from which THC, CBD, and CBC are synthesized.
Cannabinol (CBN)
A mildly psychoactive cannabinoid formed by the oxidative degradation of THC. Accumulates as cannabis ages or is exposed to heat and light.
Cannabichromene (CBC)
A non-intoxicating phytocannabinoid that does not bind significantly to CB1 or CB2 receptors but interacts with TRP channels.